Sleep in Humans Stabilizes Pattern Separation Performance

Pattern Separation Performance in Parkinson ’ s Disease Suggests Dentate Gyrus

Background: Destruction of dopaminergic neurones decreases hippocampal Dentate Gyrus (DG) neurogenesis in rodents and primates. Post-mortem work in Parkinson’s Disease (PD) patients identified evidence of compromised hippocampal neurogenesis. In both animals and man, difficult discriminations in tests which require discrimination between previously seen objects and closely similar ones (object ...

Sustained hyperoxia stabilizes breathing in healthy individuals during NREM sleep.

The present study was designed to determine whether hyperoxia would lower the hypocapnic apneic threshold (AT) during non-rapid eye movement (NREM) sleep. Nasal noninvasive mechanical ventilation was used to induce hypocapnia and subsequent central apnea in healthy subjects during stable NREM sleep. Mechanical ventilation trials were conducted under normoxic (room air) and hyperoxic conditions ...

Successful retrieval of competing spatial environments in humans involves hippocampal 1 pattern separation mechanisms 2 3

Successful retrieval of competing spatial environments in humans involves hippocampal pattern separation mechanisms

The rodent hippocampus represents different spatial environments distinctly via changes in the pattern of "place cell" firing. It remains unclear, though, how spatial remapping in rodents relates more generally to human memory. Here participants retrieved four virtual reality environments with repeating or novel landmarks and configurations during high-resolution functional magnetic resonance i...

Homeostatic regulation of REM sleep in humans during extended sleep.

Benington and Heller (1994) recently proposed a sleep-dependent model for the homeostatic control of REM sleep in which the amount of REM sleep propensity discharged in each bout of REM sleep affects the timing of the subsequent REM episode. Consistent with their hypothesis, they reported that in rats the duration of a REM episode was positively correlated with the duration of the succeeding NR...